Programme

• Sunday
• Monday
• Tuesday
• Wednesday
• POSTERS

• Sunday, 3 September
  14:00-18:00	Registration
  15:30-17:30	Trainee Workshop      ["Harry Graf Kessler 1+2" room] Assessment of mitochondrial respiratory capacity
  15:30-15:50	Yan Burelle (Ottawa, ON, Canada) How to get to the mitochondria: isolated mitochondria, permeabilized fibers, intact cells and tissue
  15:50–16:20	A brief introduction to experimental platforms - Andrew Murray - Seahorse XF Analyser, Yan Burelle
  16:20-16:40	Andrew Murray (Cambridge, United Kingdom) Substrates, inhibitors and uncouplers. How to design protocols for the analysis of respiratory capacity
  16:40-16:50	Break
  16:50–17:10	Trainee talks
  17:10–17:30	Discussion with focus on techniques

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  Opening Session     ["Harry Graf Kessler 1+2" room]
  18:00-18:15	Welcome to Weimar Christine Des Rosiers, Michael Schwarzer, Torsten Doenst
  18:15-19:15	Keynote Speaker Steve Britton (Ann Arbor, MI, USA) Theoretical and biologic evaluation of the link between low exercise capacity and disease risk
  19:30	Informal dinner reception

• Monday, 4 September
  7:00-7:30	Social programme: Johann Wolfgang von Goethe and exercise Jogging through the “Park an der Ilm” and along “Goethe's Summer House”
  Session 1 — Metabolic modulators of contractile function in health and disease      ["Harry Graf Kessler 1+2" room] Chairs: Christine Des Rosiers and Michael Schwarzer
  8:30-8:50	Volker Adams (Leipzig, Germany) Impact of exercise training on cardiovascular disease and risk
  8:55-9:15	Andrew Murray (Cambridge, United Kingdom) The impact of dietary manipulation on cardiac energetics and function
  9:20-9:40	Peter Crawford (St. Louis, MO, USA) Integrative ketone body metabolism and the pathologically remodeling heart
  	Short talks selected from submitted abstracts
  9:45-9:55	Danielle Murashige (Philadelphia, PA, USA) Promotion of cardiac branched chain amino acid metabolism does not prevent heart failure
  10:00-10:10	Craig Lygate (Oxford, United Kingdom) Mitochondrial creatine kinase overexpression protects against myocardial ischaemia-reperfusion injury
  10:15-11:00	Coffee break
  11:00-11:20	Rosalind Coleman (Chapel Hill, NC, USA) Ablating cardiac fatty acid oxidation: the good and the bad
  	Short talks selected from submitted abstracts
  11:25-11:35	Christoph Koentges (Freiburg, Germany) Lack of SIRT4 protects from myocardial ischemia reperfusion injury
  11:40-11:50	E. Dale Abel (Iowa City, IA, USA) Reducing hypoxia-inducible factor 1α expression ameliorates cardiac dysfunction in mitochondrial pyruvate carrier 1 deficient hearts
  12:00-13:00	Lunch
  Session 2 — Metabolism and excitation contraction coupling      ["Harry Graf Kessler 1+2" room] Chairs: Ellen Aasum and Heiko Bugger
  13:00-13:20	E. Douglas Lewandowski (Orlando, FL, USA) Implications of remodeled substrate oxidation on cardiac function and pathological hypertrophy
  13:25-13:45	Stefan Wagner (Regensburg, Germany) Disturbed Na and Ca metabolism in heart failure and beyond
  13:50-14:10	Ole-Jakob How (Tromsø, Norway) Energetics of inotrope treatment in acute heart failure; new drugs and old ones revisited
  	Short talks selected from submitted abstracts
  14:15-14:25	Dunja Aksentijevic (London, United Kingdom) Causal link between intracellular Na overload and metabolic remodeling in the heart: uncoupling ATP supply and demand?
  14:30-14:40	Xiao-Wei Chen (Beijing, China) The CMRD gene SAR1B maintains muscle homeostasis and function
  14:45-14:55	Roselle Gélinas (Montreal, QC, Canada) A severe inherited arrhythmia syndrome highlights the role of very-long chain fatty acid (VLCFA) metabolism in the regulation of cardiac electrical activity
  15:00-15:30	Coffee break
  Session 3 – The "William C. Stanley" Early Investigator Awards      ["Harry Graf Kessler 1+2" room] Chairs: Regine Heller and Jan Glatz
  15:30-15:40	Matthieu Ruiz (Montreal, QC, Canada) Does mitochondrial dysfunction (MD) impact on peroxisomal metabolism? A proof of concept in patients with mitochondrial disease and with heart failure (HF)
  15:45-15:55	Manoja Brahma (Birmingham, AL, USA) Glucose-mediated regulation of myocardial ketone body metabolism via increased protein O-GlcNAcylation
  16:00-16:10	Maria da Luz Sousa Fialho (Oxford, United Kingdom) Pharmacologically harnessing hypoxia signalling to improve metabolism and function in diabetes
  16:15-16:25	Margaret Nelson (Greenville, NC, USA) Monoamine oxidase metabolism of norepinephrine disrupts OxPHOS efficiency in diabetic human myocardium: therapeutic potential of L-carnosine
  16:30-17:30	Poster Session I      ["Harry Graf Kessler 3+4" room]
  19:00-21:00	Dinner

• Tuesday, 5 September
  6:45-7:30	Social programme: Jogging through the “Park an der Ilm” Cultural exercise to Castle Belvedere (8 km)
  Session 4 – Hot metabolic mechanisms for cardiac disease      ["Harry Graf Kessler 1+2" room] Chairs: E. Dale Abel and Torsten Doenst
  8:30-9:30	Keynote Speaker Howy Jacobs (Helsinki, Finland) Alternative respiratory enzymes for treating mitochondrial pathologies
  9:30-9:50	Peter Rehling (Göttingen, Germany) Dysregulation of mitochondrial proteins as a cause for cardiac failure
  9:55-10:15	Åsa Gustafsson (San Diego, CA, USA) Mitochondrial quality control in heart failure
  10:20-10:40	Coffee break
  10:40-11:00	Yan Burelle (Ottawa, ON, Canada) Mitochondrial quality control in the heart: from mitophagy to mitochondrial derived vesicles
  	Short talks selected from submitted abstracts
  11:05-11:15	Edith Renguet (Brussels, Belgium) Metabolism and acetylation contribute to leucine-mediated inhibition of cardiac glucose uptake
  11:20-11:30	Mark Pepin (Birmingham, AL, USA) Epigenetic coactivator GADD45B contributes to DNA demethylation via metabolic substrate-dependent mechanism
  11:35-11:45	Lisa Heather (Oxford, United Kingdom) Depletion of succinate mediates impaired Hypoxia-Inducible Factor 1α signalling by fatty acids in insulin resistance
  12:00-12:50	Lunch
  13:00-14:00	Poster Session II      ["Harry Graf Kessler 3+4" room]
  Session 5 – Metabolism and inflammation and its relation to contractile function      ["Harry Graf Kessler 1+2" room] Chairs: Heinrich Taegtmeyer and Michael Bauer
  14:00-14:20	Mervyn Singer (London, United Kingdom) Mitochondrial dysfunction as cause of septic organ failure and mitochondria as target for sepsis treatments
  14:25-14:45	Sina Coldewey (Jena, Germany) Sphingosine-1-phosphate and its receptors – a novel therapeutic approach to improve sepsis-induced cardiomyopathy
  14:50-15:10	Michael Sack (Bethesda, MD, USA) Mitochondrial nutrient sensing, immune activation and cardiovascular risk
  15:15-15:45	Coffee break
  	Short talks selected from submitted abstracts
  15:45-15:55	Marine Ferron (Nantes, France) In early phase of septic shock, O-GlcNAc increase shows beneficial cardiovascular effects with calcium homeostasis modifications
  16:00-16:10	Florin Despa (Lexington, KY, USA) Myocyte-capillary mismatch and myocardial capillary loss provoked by diabetes-associated hyperamylinemia
  16:30-18:00	Discover Weimar
  18:30-19:00	Transfer to the dinner location
  19:00-24:00	Gala Dinner at Planetarium Jena
  	Honorary Dinner Lecture Franz von Falkenhausen (Jena, Germany) Jena – the science city and Carl Zeiss Historical insights from a “Zeissianer”

• Wednesday, 6 September
  7:00-7:30	Social programme: Jogging through “Goethepark” along the Ilm to the “six arches bridge” and the “City Palace” of the Dukes of Weimar
  8:30-9:30	"William C. Stanley" Keynote Lecture      ["Harry Graf Kessler 1+2" room] Heinrich Taegtmeyer (Houston, TX, USA) Side-by-side: exploring the pervasive roles of metabolism in cancer and the heart
  Session 6 - Clinical relevance and “transferability”      ["Harry Graf Kessler 1+2" room] Chair: P. Christian Schulze
  9:30-9:50	Linda Peterson (St. Louis, MO, USA) Dietary nitrate and skeletal muscle performance in heart failure
  9:55-10:15	Vera Schrauwen-Hinderling (Maastricht, Netherlands) Metabolic derangements in insulin resistance and diabetes: insights from Magnetic Resonance Spectroscopy studies
  10:20-10:40	Petra Kleinbongard (Essen, Germany) Cardiac protection and metabolic treatment trials: an update
  10:45-11:10	Coffee break
  	Short talks selected from submitted abstracts
  11:10-11:20	Kerstin Timm (Oxford, United Kingdom) Hyperpolarized 13C magnetic resonance spectroscopy reveals real-time metabolic flux changes in a rat model of doxorubicin-induced cardiotoxicity
  11:25-11:35	Damian Tyler (Oxford, United Kingdom) Assessment of physiological alterations in human cardiac metabolism using hyperpolarised 13C MR spectroscopy
  11:40-11:50	Invitation to SHVM 2018      ["Harry Graf Kessler 1+2" room]
  11:50-12:00	Concluding remarks      ["Harry Graf Kessler 1+2" room] Christine Des Rosiers, Michael Schwarzer, Torsten Doenst
  12:00	Buffet lunch and Adjourn

• Posters

  When preparing your poster, please remember that its maximum size is 90 x 120 cm (width x height). Note that the orientation is portrait, not landscape.

  Correct format...    Wrong format...

  The exact distribution of posters in the two sessions is indicated below.

  Independently of the session to which you have been assigned, you are kindly invited to put up your poster in time for the first poster session, scheduled for Monday, 4 September, at 16:30. All posters should stay up for the entire duration of the meeting. Poster presenters are required to be available for discussion during their assigned session.

  • Session 1
  • Session 2

  • Poster Session 1

    Monday, 4 September • 16:30-17:30

    P1.1 · E. Dale Abel (Iowa City, IA, USA)
    Reducing hypoxia-inducible factor 1α expression ameliorates cardiac dysfunction in mitochondrial pyruvate carrier 1 deficient hearts

    P1.2 · Rami A. Al Batran (Edmonton, AB, Canada)
    FoxO1 regulates myocardial glucose oxidation rates via transcriptional control of pyruvate dehydrogenase kinase 4 expression

    P1.3 · Preetha Balakrishnan (Jena, Germany)
    The impact of metabolic stress on autophagy

    P1.4 · Heiko Bugger (Freiburg, Germany)
    Gene expression analysis to identify mechanisms underlying heart failure susceptibility in mice and humans

    P1.5 · Xiao-Wei Chen (Beijing, China)
    The CMRD gene SAR1B maintains muscle homeostasis and function

    P1.6 · Florin Despa (Lexington, KY, USA)
    Myocyte-capillary mismatch and myocardial capillary loss provoked by diabetes-associated hyperamylinemia

    P1.7 · Madelene Ericsson (Umeå, Sweden)
    Cold treatment causes a metabolic shift and improves cardiac function and in C57/Bl6 mice

    P1.8 · Roselle Gélinas (Montreal, QC, Canada)
    A severe inherited arrhythmia syndrome highlights the role of very-long chain fatty acid (VLCFA) metabolism in the regulation of cardiac electrical activity

    P1.9 · Jin Han (Busan, Republic of Korea)
    Mitochondrial function in stem cell differentiation to cardiac myocytes

    P1.10 · Maximilian E. Hölscher (Freiburg, Germany)
    SIRT4 regulates fatty acid utilization and contractile function in the normal and diabetic heart

    P1.11 · Ruiping Ji (New York, NY, USA)
    Depletion of myocardial long chain fatty acid and free acylcarnitine in patients with advanced heart failure

    P1.12 · Jaetaek Kim (Seoul, Republic of Korea)
    Cx43 and ZO-1 are targets of Akt in cardiomyocytes and are associated with cardiac contractile dysfunction

    P1.13 · Christoph Koentges (Freiburg, Germany)
    Overexpression of SIRT4 accelerates the development of heart failure following transverse aortic constriction

    P1.14 · Bettina J. Kraus (Würzburg, Germany)
    Increased cardiac glucose uptake causes hypoglycemia and mortality in heart failure

    P1.15 · Ross T. Lindsay (Cambridge, United Kingdom)
    Ketogenesis in the ischaemic rat heart

    P1.16 · Jubert C. Marquez (Busan, Republic of Korea)
    Cardioprotective role of mitochondrial malate dehydrogenase (MDH2) phosphorylation in hypoxia/reoxygenation of cardiac cells

    P1.17 · Danielle S. Murashige (Philadelphia, PA, USA)
    Promotion of cardiac branched chain amino acid metabolism does not prevent heart failure

    P1.18 · Margaret A. Nelson (Greenville, NC, USA)
    Monoamine oxidase metabolism of norepinephrine disrupts OxPHOS efficiency in diabetic human myocardium: therapeutic potential of L-carnosine

    P1.19 · Kyu-Sang Park (Wonju, Republic of Korea)
    Inhibition of mitochondrial phosphate transport prevents phosphate-induced vascular calcification

    P1.20 · Tina M. Pedersen (Tromsø, Norway)
    Myocardial substrate utilization and efficiency are unaltered in Angiotensin II-induced compensatory hypertrophy

    P1.21 · Jeanine J. Prompers (Utrecht, Netherlands)
    Administration of a single dose of empagliflozin acutely improves cardiac energy status in diabetic mice

    P1.22 · Sarah Reiners (Jena, Germany)
    Genetic predisposition for high intrinsic exercise capacity reduces cardiac performance during pressure overload

    P1.23 · Lars Rødland (Tromsø, Norway)
    Oxygen wastage following adrenergic stimulation is linked to intermediary metabolism and not contractility – a large animal study

    P1.24 · Dragana Savic (Oxford, United Kingdom)
    Improved cardiac pyruvate metabolism with carnitine supplementation in the type 1 diabetic heart: an in vivo hyperpolarized MRS study

    P1.25 · Andrea Schrepper (Jena, Germany)
    Cardiac contractile and mitochondrial function in sepsis and their relation to sepsis severity

    P1.26 · Kerstin Nina Timm (Oxford, United Kingdom)
    Hyperpolarized ¹³C magnetic resonance spectroscopy reveals real-time metabolic flux changes in a rat model of doxorubicin-induced cardiotoxicity

    P1.27 · Darya Zibrova (Jena, Germany)
    AMPK-dependent phosphorylation of GFAT1 inhibits HBP and promotes VEGF-induced angiogenesis in endothelial cells

    P1.28 · Rudin Pistulli (Jena, Germany)
    Metabolomic profiling of patients with myocarditis correlates with disease severity

    P1.29 · Xiaokan Zhang (New York, NY, USA)
    miR-195 regulates myocardial metabolism in heart failure via alterations in SIRT3 expression and mitochondrial protein acetylation profile

    P1.30 · Tom Kretzschmar (Jena, Germany)
    Characterization of ceramide signaling and its metabolic effects in cardiomyocytes
     

  • Poster Session 2

    Tuesday, 5 September • 13:00-14:00

    P2.1 · Azrul Bin Abdul Kadir (Oxford, United Kingdom)
    Glycogen content alters ketone body oxidation in the isolated rat heart

    P2.2 · Dunja Aksentijevic (London, United Kingdom)
    Causal link between intracellular Na overload and metabolic remodeling in the heart: uncoupling ATP supply and demand?

    P2.3 · Sun Sik Bae (Yansan-si, Republic of Korea)
    Phospholipase C-β3 plays an essential role in vascular remodeling

    P2.4 · Manoja K. Brahma (Birmingham, AL, USA)
    Glucose-mediated regulation of myocardial ketone body metabolism via increased protein O-GlcNAcylation

    P2.5 · Fang Cao (Oxford, United Kingdom)
    Mitochondrial creatine kinase overexpression in a murine model of chronic heart failure

    P2.6 · Cher-Rin Chong (Oxford, United Kingdom)
    The relation between ketone body oxidation and energy metabolism in rat heart

    P2.7 · Justine Dhot (Nantes, France)
    Identification of targets involved in the pathophysiology of heart failure with preserved ejection fraction

    P2.8 · Marine Ferron (Nantes, France)
    In early phase of septic shock, O-GlcNAc increase shows beneficial cardiovascular effects with calcium homeostasis modifications

    P2.9 · Dale J. Hamilton (Houston, TX, USA)
    High-fat diet impacts diastolic function in ovariectomized mice

    P2.10 · Estelle Heyne (Jena, Germany)
    Low intrinsic exercise capacity is associated with advanced mitochondrial dysfunction during aging

    P2.11 · Kirsten M. Jansen (Tromsø, Norway)
    Dietary and pharmacological anti-obesogenic treatments improve myocardial metabolism in diet-induced obese mice

    P2.12 · Hyoung Kyu Kim (Busan, Republic of Korea)
    Mitochondrial modulation of cardiac differentiation from mouse embryonic stem cells via pyruvate dehydrogenase phosphatase 1

    P2.13 · Christoph Koentges (Freiburg, Germany)
    Lack of SIRT4 protects from myocardial ischemia reperfusion injury

    P2.14 · Hyun Kook (Hwasun-gun, Jeollanam-do, Republic of Korea)
    Sumoylation of histone deacetylase 1 regulates MyoD signaling during myogenesis

    P2.15 · Sophie Lepropre (Brussels, Belgium)
    Phosphorylation of acetyl-CoA carboxylase by AMPK in platelets controls thromboxane generation, dense granules secretion and thrombus formation

    P2.16 · Joost J.F.P. Luiken (Maastricht, Netherlands)
    Live cell imaging reveals CD36 translocation to the sarcolemma upon myocelular lipid oversupply to be mediated by v-ATPase disassembly

    P2.17 · Nobutoshi Matsumura (Edmonton, AB, Canada)
    Doxorubicin treatment of young mice induces hypertension and cardiac dysfunction in response to cardiac stress in adulthood

    P2.18 · Zibele Ndlovu (Cape Town, South Africa)
    Vascular alterations in diet-induced obese rats: role of exchange protein directly activated by cyclic AMP (Epac)

    P2.19 · Chan Bae Park (Suwon, Republic of Korea)
    Generation of cardiovascular disease model by expanding the genetic code in mouse

    P2.20 · Nammi Park (Busan, Republic of Korea)
    Identification of mitochondrial function and mechanism through post-translational modifications of mitochondrial creatine kinase (CKMT2)

    P2.21 · Mark E. Pepin (Birmingham, AL, USA)
    Epigenetic coactivator GADD45B contributes to DNA demethylation via metabolic substrate-dependent mechanism

    P2.22 · Erin L. Reineke (Houston, TX, USA)
    Activation of metabolic sensor AMPK primes hearts to tolerate left ventricular pressure overload

    P2.23 · Edith D. Renguet (Brussels, Belgium)
    Metabolism and acetylation contribute to leucine-mediated inhibition of cardiac glucose uptake

    P2.25 · Christina Schenkl (Jena, Germany)
    Rats with high or low Intrinsic exercise capacity subjected to pressure overload - analysis of survival, cardiac and mitochondrial function

    P2.26 · Mitchel Tate (Melbourne, VIC, Australia)
    Cardiac-selective bone morphogenetic protein 7 (BMP7) gene therapy effectively targets cardiac fibrosis in a mouse model of diabetic cardiomyopathy

    P2.27 · Damian J. Tyler (Oxford, United Kingdom)
    Assessment of physiological alterations in human cardiac metabolism using hyperpolarised ¹³C MR spectroscopy

    P2.28 · P. Christian Schulze (Jena, Germany)
    Prognostic impact of serum metabolomic profiling in patients with heart failure with reduced ejection fraction

    P2.29 · Mohamed M. Bekhite ELsaied (Jena, Germany)
    Differential metabolic expression of genes between early and late cardiomyocytes derived from human-induced pluripotent stem cells as a novel in vitro model for the investigation of cardiac metabolism in diabetes mellitus

    P2.30 · Kelsey S. Moore (Charleston, SC, USA)
    Ceramide synthases contribute to cardiomyocyte dysfunction in diabetic cardiomyopathy independently and potentially as heterodimers